Cell banking

Pilot-scale manufacturing

Commercial manufacturing

TOT BIOPHARM runs a commercial GMP production base, equipped with specific cell bank and drug substance production lines. We provide MCB and WCB production, and produce drug substances in 200 L, 500 L, and 2,000 L bioreactors, with a total capacity exceeding 20,000 L.

– Equipped with global leading equipment, including Cytiva's single-use bioreactors and chromatography systems, as well as Millipore/PALL's ultrafiltration systems.

– Adaptable techniques to support diverse multi-batch and specification requirements.

– With extensive experience, TOT has produced numerous drug substances, including batches for market-launched products.

Disposable bioreactor

Disposable dispensing system with weighing module

Automated TFF ultrafiltration system

Automated liquid chromatography systems with chromatography columns